![]() For these reasons, a need for alternative synergistic therapies or dietary supplements to face cancer becomes a must. This decrease will greatly affect the present treatment protocols with time. The response rates to the available cancer chemotherapeutics are decreasing. For the coming generations, chemotherapy complications and multidrug resistance will be a serious threat. According to the World health organization (WHO) report 2050, 27 million cancer cases and 17.1 million death cases will be registered per year. It is caused by an abnormal cell DNA mutation leading to cellular imbalance, and an uncontrolled spread prior to secondary damage of the body organs. Cancer is a disease which has spread globally and is considered to be one of the most common causes of death worldwide. These unique properties of RJ, besides possessing minimal toxicity compared with other bee products, make it the best choice to be combined with anticancer drugs. It is also used in pharmaceutical preparations and as an industrial cosmetic agent. RJ has recently shown anticancer, antioxidant, anti-microbial, anti-aging, and anti-inflammatory pharmacological properties, making it a dietary supplement with functional health-enhancing criteria. However, in the last years, the interest in the food industry and natural products has greatly increased, highlighting the importance of RJ and its unique pharmacological and therapeutic properties. It has been utilized in conventional medicine, particularly in Asia and Ancient Egypt. ![]() For generations, fresh RJ has been used as an alternative remedy and an all-natural energy booster. Bioactive peptides are responsible for most of the unique therapeutic actions of RJ. Naturally occurring bioactive peptides comprise the highest percentage of RJ active ingredients. It contains proteins, water, and sugar as major components, while the minor components are composed of minerals, amino acids, vitamins, enzymes, and hormones. RJ is partially water soluble and highly acidic, with a gelatinous consistency. On the other hand, the hypopharyngeal gland is a pair of long tuberous organs found in the worker bee’s frontal head regions. The mandibular gland is a pair of sacs that can only be found in worker bees and the queen. RJ is produced by both the mandibular and hypopharyngeal glands, although only the hypopharyngeal gland is involved in protein synthesis. It is known as a “superfood” since it serves as the primary source of nutrition for young worker larvae for the first three days and for the lifetime of the queens. RJ is a hypopharyngeal and mandibular glandular secretion of nurse honey bees. Royal jelly (RJ) is one of the honey bee products that has attracted much attention recently. The purpose of the present review is to emphasize the possible interactions between chemotherapy and RJ, or its components, in treating cancer illnesses. The combination of RJ or its constituents with anticancer drugs has synergistic effects on cancer disorders, enhancing the drug’s effectiveness or reducing its side effects. Antioxidant, anticancer, anti-inflammatory, antidiabetic, and antibacterial impacts are among the well-recognized benefits. RJ contains bioactive substances, such as carbohydrates, protein, lipids, peptides, mineral salts and polyphenols which contribute to the appreciated biological and pharmacological activities. One of these agents, and a very notable food agent, is royal jelly (RJ), known to be produced by the hypopharyngeal and mandibular salivary glands of young nurse honeybees. ![]() The above notion, plus the trend in going back to nature, encourages consumers and the food industry to invest more in food products and to find potential candidates that can maintain human health. A healthy lifestyle, especially a nutritional diet, plays a critical role in the treatment and prevention of many disorders, including cancer. Currently, various methods are used to treat cancer, including radiotherapy, surgery, and chemotherapy, all of which have serious adverse effects. Cancer is one of the major causes of death globally.
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